Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin.

The Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells

Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...

Glial Cell Line-derived Neurotrophic Factor and Neurturin in the Regulation of Spermatogenesis

Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons.

Neuregulins (NRGs) are expressed in spinal cord motor neurons and accumulate at the neuromuscular junction where they may increase the synthesis of postsynaptic acetylcholine receptors and voltage-gated sodium channels. We demonstrate here that NRG expression is selectively increased in rat ventral spinal cord neurons at approximately the time that nerve-muscle synapses first form. A rapid incr...

Glial Cell Line-derived Neurotrophic Factor, Neurturin and Their Receptors in the Development, Maintenance and Plasticity of the Nervous System

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Retrograde signaling onto Ret during motor nerve terminal maturation.

Establishment of the neuromuscular synapse requires bidirectional signaling between the nerve and muscle. Although much is known on nerve-released signals onto the muscle, less is known of signals important for presynaptic maturation of the nerve terminal. Our results suggest that the Ret tyrosine kinase receptor transmits a signal in motor neuron synapses that contribute to motor neuron surviv...